Strain Library

Unlike most probiotics, which simply pass through, this strain attaches to the lining of the large intestine. It supports the gut's own protective mucus layer and produces short-chain fatty acids — the compounds cells lining the colon use as fuel. Its effect on iron is separate: it acts on the conversion step in the small intestine that makes iron from food absorbable.

The digestive and iron research are separate bodies of work, at different dose schedules — iron is studied taken with an iron-containing meal.

This strain attaches to the gut lining using hair-like surface structures — an unusually strong grip that lets it hold its place through periods when the normal balance of gut bacteria is disrupted, and occupy space that would otherwise be available to less welcome bacteria.

Taken during pregnancy and breastfeeding, this strain helps shape the mix of bacteria an infant's gut establishes in its first months — the window in which the developing immune system is learning what to react to. In the mother, it was studied along the pathways the body uses to make mood-related signalling compounds.

In the same trial, a companion strain tested alongside it showed no effect — one of the clearest demonstrations that a result belongs to a specific strain, not to probiotics generally.

Studied for its effect on the immune signalling balance that sits underneath atopic tendencies.

A single-strain product. The childhood airway combination is a separate product, which pairs this strain with B632.

A vaginal microbiome in good order is usually one where Lactobacillus crispatus is the dominant organism. It produces lactic acid — including the D-form, which most other vaginal lactobacilli do not — and hydrogen peroxide, together maintaining the low pH that characterises a stable vaginal environment.

Included in the formulation as a key vaginal strain. The recurrence research was conducted on the LA02 + LF10 combination, which is shown as a separate entry.

Together

The two strains work at different levels — one sets the conditions, the other settles in and holds them.

Each strain’s role

• L. acidophilus LA02 (DSM 21717)

  Produces lactic acid as its only acid, maintaining the naturally acidic environment a healthy vaginal microbiome depends on.

• L. fermentum LF10 (DSM 19187)

  Forms a biofilm on the vaginal lining, so it stays in place rather than passing through, and produces its own antimicrobial compounds.

Together

Only as a set of four did the blend increase the proteins that seal the gut lining. Each strain contributes a different piece.

Each strain’s role

• B. longum 04 (DSM 23233)

  Studied for supporting the viability of gut lining cells under stress.

• L. plantarum LP01 (LMG P-21021)

  Crowds out unwanted bacteria, and was the strain that reduced oxidative stress.

• L. rhamnosus LR06 (DSM 21981)

  Works with LP01 as the most effective pair at crowding out unwanted bacteria.

• L. fermentum LF16 (DSM 26956)

  The strongest of the four at supporting the integrity of the gut lining.

Together

The skin and the gut are linked by immune and inflammatory signalling. In trial, the combination shifted the balance of bacteria living on the face and reduced oil production.

Each strain’s role

• L. salivarius LS03 (DSM 22776)

  Produces compounds active against the bacteria associated with breakouts, and dampens one of the signals that draws inflammatory cells to the skin.

• B. breve BR03 (DSM 16604)

  Contributes the anti-inflammatory side, shifting immune signalling.

L. casei LC03 (DSM 27537) was part of the studied formulation but has not been characterised on its own. The trial formulation also included lupeol and echinacea.

Together

Together the pair were studied for keeping baseline immune activity in check — priming without tipping into unnecessary inflammation. Both settle in the gut after being swallowed.

Each strain’s role

• L. paracasei 8700:2 (DSM 13434)

  Primes the immune cells that act first against viruses, within about two weeks.

L. plantarum HEAL9 (DSM 15312) was studied as part of the pair rather than individually.

Together

Both strains were studied for crowding out the gut bacteria associated with colic. Bottle-fed infants typically do not establish B. breve on their own, which is the reasoning behind supplying it directly.

Each strain’s role

• B. breve BR03 (DSM 16604)

  Produces its own inhibitory compounds, beyond simply making the environment more acidic.

• B. breve B632 (DSM 24706)

  Studied for supporting the integrity of the gut lining.

Together

Atopic tendencies in the skin and the airways share an underlying immune signalling pattern. This pairing was studied along that shared pathway.

Each strain’s role

• L. salivarius LS01 (DSM 22775)

  Studied for its effect on the immune signalling balance underlying atopic tendencies.

• B. breve B632 (DSM 24706)

  Studied for supporting the integrity of the gut lining.

A separate product from the adult skin research, which studied LS01 on its own.

Together

The mouth has its own microbiome, and these four were selected to act on it directly — which is why the format dissolves in the mouth instead of passing through to the gut. Between them they compete for space on the tooth surface and gum tissue, produce their own antimicrobial compounds, and shift saliva towards the less acidic end of its range.

Each strain’s role

• L. rhamnosus Rosell-11

  Sticks to the tooth surface and gum tissue, competing for the binding sites that less welcome oral bacteria would otherwise take.

• S. boulardii CNCM I-1079

  A yeast rather than a bacterium. Studied for its effect on the inflammatory signalling behind gum irritation.

• L. acidophilus Rosell-52

  Contributes to the antimicrobial side of the blend and to raising the salivary antibodies that form part of the mouth's own defences.

• B. longum Rosell-175

  Works alongside the others on the overall balance of the oral microbiome.

Studied as a fixed four-strain blend. Individual contributions are drawn from the wider literature on each strain rather than separated out within these trials.

Together

Both strains settle into the colon and increase production of short-chain fatty acids, which lower the acidity of the bowel and prompt the muscular contractions that move things along. The same shift draws more water into the stool, and reduces the fermentation discomfort that tends to accompany sluggish transit.

Each strain’s role

• L. plantarum LP01 (LMG P-21021)

  Adheres to and colonises the intestinal lining — confirmed in a dedicated colonisation study comparing coated and uncoated strains.

• B. breve BR03 (DSM 16604)

  Works with LP01 on the colonic balance that drives short-chain fatty acid production.

Studied as a fixed two-strain blend at 2.5 billion CFU of each strain.

Together

All three strains carry unusually high activity of an enzyme that acts on bile acids. Because the body makes bile acids out of cholesterol, changing how those acids are recycled changes how much cholesterol the liver draws on to replace them.

Each strain’s role

• L. plantarum CECT 7528

  Shows by far the highest direct cholesterol binding of any strain tested against it.

CECT 7527 and CECT 7529 were studied as part of the fixed three-strain combination rather than individually.

Bone is continually broken down and rebuilt, and immune signalling influences which side of that balance wins. This combination was studied along that gut–bone pathway, including the short-chain fatty acids produced when the strains ferment fibre in the colon.

These three strains were identified and studied together as a fixed combination. Individual contributions have not been separated out.